"Office 12" will do PDF and the PDFs will be accessible
At the MVP Summit, Steven Sinofsky, senior vice president of Microsoft(r) Office at Microsoft Corp., made a major announcement about the next version of Office - currently known as "Office 12". PDF support will be built into Word, Excel, PowerPoint, Access, Publisher, OneNote, Visio, and InfoPath - and yes, the PDF documents will be accessible. Sinofsky said that this was the second most requested feature in Office - we didn't get a chance to ask what the first most requested feature was.
http://blogs.msdn.com/brian_jones/archive/2005/10/01/476067.aspx