Workaround for InstallShield re-activation problem
With InstallShield version 2010 Flexera Software introduced the requirement that activation of the software has to be repeated yearly. Typically this re-activation happens automatically without user interaction. However in some cases, the automatic re-activation fails and when trying to manually re-activate some users get an error message: "The license for this computer is in use on another computer. ... Error 20653 - The number of activations allowed for this account has been exceeded."

Flexera Software has documented a workaround for this problem in knowledge base article Q212463.