TinyCLR
According to http://wintellect.com/WEBLOGS/wintellect/archive/2004/09/18/464.aspx, Jeffrey Richter will be working with TinyCLR (the kind that will or already does provide the platform for MSN watches) to do some cool-ass stuff. Not much details, but check it out nevertheless.
I wonder how different this will be from JME and others.