Issues ... Access ...Windows Vista (or Windows Server 2008)
See Issues that you may encounter when you open or are using a Microsoft Office Access database on a computer that is running Windows Vista - 935370. Note that this is an SMB 2.0 issue and thus Windows Server 2008 could also have this problem. Looks like this could be similar in some respects to the OpLocks problem back when Windows 2000 Server was introduced.
The Access Corruption Symptoms, Causes and Access Performance pages have been updated.
Edit: Changed Small Business Server 2003 to Windows Server 2008 as per Susan Bradley's query posting. I got confused between the SMB signing problem and SMB 2.0. See New Networking Features in Windows Server 2008 and Windows Vista and do a search on SMB 2.0. Added links to various Access pages.